肠道微生物失调症在两种不同的卡切克性瘤载体模型中存在差异,它们都食用相同的饮食
Lauri O Byerley1, Brittany Lorenzen1, Hsiao-Man Chang1
1Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA.
Nutrients
|April 13, 2024
概括
癌症缓冲症根据瘤类型不同地改变肠道微生物群,而核桃丰富的饮食会影响细菌生长,但不会减缓缓冲症的进展. 这表明癌症缓解症涉及的复杂因素超出了肠道微生物群的变化.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 癌症缓解症显著影响患者的健康和生活质量.
- 癌症缓解症和结肠微生物群之间的关系尚不清楚.
- 调查肠道微生物组在缓冲症中的作用可能会揭示新的治疗点.
研究的目的:
- 评估两种不同类型的瘤如何影响大鼠肠道微生物群.
- 为了确定核桃丰富的饮食是否可以减轻缓解性诱导的肠道失生症.
- 探索饮食干预措施在治疗癌症缓解症方面的潜力.
主要方法:
- 344只Fisher雄性大鼠被食了对照饮食或补充了核桃的饮食.
- 确立了携带瘤 (大肠癌或MCA诱导的肉瘤) 和非携带瘤的组.
- 用16S rRNA基因测序来分析便样本,以确定细菌物种.
主要成果:
- 两组瘤携带者都出现了卡赫西亚,但他们的肠道微生物组有明显的变化.
- 饮食显著影响了细菌种群的丰富性 (例如,控制饮食增加了A. anaeroplasma,核桃饮食增加了Ruminococcus).
- 在不同瘤类型或治疗方法中,没有确定任何一致的便细菌变化是缓冲症的特征.
结论:
- 癌症缓解症诱导各种肠道微生物组变化,具体取决于瘤类型.
- 用核桃进行的饮食干预改变了肠道微生物群,但并没有减缓缓症的进展.
- 癌症缓冲症是一种复杂的疾病,受简单肠道微生物群转移之外的因素的影响.
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