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计算机断层扫描软组织测量与药物诱导睡眠内镜上空气道缩性之间的关联

Eric R Thuler¹, Manan H Parekh¹, Jules G Rodin¹

¹Department of Otorhinolaryngology, Division of Sleep Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|April 13, 2024

概括

更大的舌头体积与阻塞性睡眠呼吸暂停 (OSA) 患者的呼吸道缩性增加有关. 这一发现来自药物诱导睡眠内镜 (DISE) 和CT扫描,突出了软组织.

科学领域:

睡眠医学睡眠医学
耳鼻喉科耳鼻喉科耳鼻喉科
放射学放射学是一门学科.

背景情况:

在药物诱导睡眠内镜 (DISE) 期间的正气道压力 (PAP) 定位提供了客观的上呼吸道折叠性测量.
以前的研究将骨测量与可折叠性联系起来,但软组织尺寸的影响仍然不清楚.

研究的目的:

为了研究上呼吸道软组织体积 (软口腔,喉侧壁,舌头) 和可折叠性指标之间的关系.
为了确定软组织尺寸是否影响阻塞性睡眠呼吸暂停 (OSA) 患者在PAP定位期间的气道折叠性.

主要方法:

来自学术医疗中心的潜在队列的横截面分析.
接受OSA PAP替代疗法的患者进行了计算机断层扫描 (CT) 扫描和DISE.
CT专注于软组织体积;DISE与PAP (DISE-PAP) 确定了喉关键压力 (PcritA) 和喉开口压力 (PhOP).

主要成果:

139名受试者完成了CT和DISE-PAP.
经过临床因素和骨体积的调整,更大的舌头体积与更积极的PhOP (ρ=0.20,P=0.02) 和PcritA (ρ=0.16,P=0.07) 相相关.
软口腔和侧壁体积与可折叠性指标没有关联;较小的后方口腔区域和内体积与可折叠性增加有关.

结论:

增加的舌头体积与OSA患者的呼吸道缩性有关,即使控制了临床和骨因素.
这些发现表明,舌头体积,可能与较小的骨尺寸相结合,对OSA严重性有很大影响.
了解软组织对气道折叠性的贡献,可以完善OSA治疗策略.

关键词:

电脑图像扫描面分析.药物诱导的睡眠内镜.睡眠呼吸暂停 (Sleep Apnea) 是一个软组织体积的软组织体积.上呼吸道崩塌的情况

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