在早期多发性硬化症中敏感识别下肢功能中的不对称性和神经肌肉缺陷
Anne Geßner1, Maximilian Hartmann1, Anikó Vágó1
1Center of Clinical Neuroscience, Neurological Clinic, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Neurorehabilitation and neural repair
|April 13, 2024
概括
单反运动跳跃 (SLCMJ) 可以检测多发性硬化症 (pwMS) 患者的早期神经肌肉缺陷和力量不对称. 这种功能性评估对于在通过传统方法变得明显之前识别亚临床问题至关重要.
科学领域:
- 神经肌肉功能 神经肌肉功能
- 生物机械分析 生物机械分析
- 临床诊断 临床诊断 临床诊断
背景情况:
- 早期多发性硬化症 (MS) 缺乏针对亚临床神经肌肉缺陷和下肢强度不对称性的敏感功能评估.
- 在强力板上的单腿反运动跳跃 (SLCMJ) 为评估单边下肢表现提供了一个潜在的解决方案.
研究的目的:
- 客观地评估多发性硬化症 (pwMS) 患者的早期下肢神经肌肉缺陷和不对称性.
- 评估SLCMJ在强力板上用于检测这些缺陷的实用性.
主要方法:
- 一组126名pwMS和97名健康对照 (HC) 进行了最大的SLCMJs.
- 记录了时间,动力和功率跳跃参数.
- 使用协差分析 (ANCOVA),对年龄,BMI和性别进行控制.
主要成果:
- 与HC相比,PwMS显示SLCMJ性能显著降低,即使具有正常的手动肌肉力量.
- 与HC相比,在pwMS中观察到跳跃性能中较大的腿主导差异.
- 推进时间的显著相互作用效应突出显示了 pwMS 中的不对称性增加,与扩展残疾状态量表 (EDSS) 得分相关.
结论:
- 应力板上的SLCMJ是一种适合用于早期检测亚临床神经肌肉缺陷的功能评估.
- 这种方法有效地识别了MS患者的下肢强度不对称.
- SLCMJ提供了关于早期MS相关神经肌肉变化的宝贵见解.
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