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在吉普赛范纳马中的马类神经轴突变/退行性髓脑病变

Alexis Powers¹, Simon F Peek¹, Steve Reed²

¹Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal of veterinary internal medicine

|April 13, 2024

概括

吉普赛范纳马可能有遗传倾向于患马类神经轴突变/退行性髓脑病变 (eNAD/EDM). 建议年轻的GV补充维生素E,以解决缺陷并预防这种神经疾病.

科学领域:

马类神经学马类神经学
营养科学营养科学
兽医遗传学兽医遗传学

背景情况:

马类神经轴突变/退行性髓脑病变 (eNAD/EDM) 是一种神经退行性疾病,影响缺乏维生素E的马.
eNAD/EDM以前没有在吉普赛范纳马 (GVs) 中被记录.

研究的目的:

调查疑似eNAD/EDM的吉普赛范纳马的临床症状,维生素E水平和血统.
通过尸检确认吉普赛范纳斯的eNAD/EDM诊断.

主要方法:

在加利福尼亚州,对26匹吉普赛范纳马进行了前性观察研究.
进行了神经学检查,补充前后维生素E血度和血统分析.
在四匹受影响的马身上获得了eNAD/EDM的尸检确认.

主要成果:

在研究的吉普赛范纳马中,有94%的维生素E水平在补充前低于正常范围 (≤2.0μg/mL).
补充后的维生素E水平有所变化,只有52%的人达到正常度 (≥3.0微克/毫升).
eNAD/EDM通过四匹被安乐死的吉普赛范纳马的尸体解剖来证实.

结论:

吉普赛范纳马可能具有开发eNAD/EDM的遗传倾向.
监测和维生素E补充对于年轻的吉普赛范纳马来说至关重要,以管理这种情况.

关键词:

阿尔法-托科菲罗尔的使用.遗传学遗传学遗传学遗传学是一个继承继承继承继承继承维生素E 维生素E 是一种维生素.

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