维生素D3,omega-3和简单的力量训练炼计划对骨健康的影响:DO-HEALTH随机对照试验
Melanie Kistler-Fischbacher1,2, Gabriele Armbrecht3, Stephanie Gängler1,2
1Department of Geriatric Medicine and Aging Research, University of Zurich, Zurich 8037, Switzerland.
概括
在老年人中,维生素D补充对关节骨总矿物质密度有很小的益处. 特别是在男性的腰椎骨密度上观察到类似的好处,而omega-3和运动没有影响.
科学领域:
- 老年学是指老年学的学科.
- 骨健康 骨健康 骨健康
- 营养科学 营养科学
背景情况:
- 关于维生素D,欧米茄-3脂肪酸和运动对健康老年人骨矿物质密度的影响的证据有限.
- 骨矿物质密度 (BMD) 是老龄化人口中骨折预防的关键因素.
研究的目的:
- 为了研究维生素D3,omega-3脂肪酸或简单的家庭运动计划 (SHEP),单独或组合,对70岁及以上的成年人三年内区域骨矿物质密度 (aBMD) 的影响.
- 评估腰椎 (LS),大腿 (FN) 和全部 (TH) 的变化 aBMD.
主要方法:
- 一项为期3年的多中心,双盲,随机2x2x2因子试验 (DO-HEALTH),涉及一般健康的老年人 (≥70岁).
- 干预措施包括维生素D3 (2000 IU/天),omega-3s (1 g/天) 和SHEP (3x30分钟/周),单独或组合使用.
- 使用DXA测量了面积 BMD,使用混合效应模型进行统计分析,并根据相关共变量进行调整. 进行了子组分析.
主要成果:
- 在任何干预措施中,在LS或FN地点没有观察到aBMD的显著益处.
- 与没有维生素D治疗相比,维生素D补充剂在3年内对TH aBMD显著有好处 (调整后平均值的差异:0.0035 g/cm2).
- 在男性子组中发现了维生素D对LS aBMD的显著益处 (相互作用P=.003). 欧米茄-3和SHEP在这个人群中对aBMD没有益处.
结论:
- 在老年人中,每天摄入2000 IU的维生素D可能对部aBMD总量有很小的益处.
- 维生素D补充剂也可能对男性的腰椎脊柱aBMD有好处,尽管效果大小适度.
- 欧米茄-3脂肪酸和简单的家庭炼计划对健康,活跃,大部分维生素D补充的老年人没有显示aBMD的益处.
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