帕佐帕尼布通过准核因子E2相关因子2 (Nrf2) 来刺激癌细胞的衰老

Xingyuan Wang1, Jing Yang1, Dechao Li1

  • 1Department of Urology, Harbin Medical University Cancer Hospital, Harbin, China.

概括

用于细胞癌 (RCC) 的帕佐帕尼布促进癌细胞衰老,并通过激活核因子E2相关因子2 (Nrf2) 来降低端粒酶活性. 沉默Nrf2阻止了这些效应,揭示了Pazopanib的一种新机制.

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