从表观遗传学到临床病理学特征:对H3G34突变扩散半球结质瘤文献进行文献分析
Jordan T Roach1,2,3, Cecile Riviere-Cazaux4,5, Brennan A Wells6
1Department of Developmental Neurobiology, Division of Brain Tumor Research, St. Jude Children's Research Hospital, Memphis, TN, USA. jordan.roach@stjude.org.
概括
这项研究分析了关于H3 G34突变扩散半球质瘤 (H3 G34 DHG) 的备受引用的出版物. 基础科学研究主导了顶级的H3 G34 DHG文献,突出了需要更多的临床研究.
科学领域:
- 神经瘤学神经瘤学
- 儿科瘤学 儿科瘤学
- 基因组学就是基因组学.
背景情况:
- 儿科类型的扩散性高度质瘤是儿童癌症死亡的主要原因.
- 在超过30%的青少年扩散半球质瘤 (DHG) 中发现了histon H3 G34突变.
- H3 G34突变型DHG (H3 G34 DHG) 被世界卫生组织认可为一个独特的瘤实体.
研究的目的:
- 通过图书统计分析,提供关于H3 G34 DHG新兴文献的概述.
- 确定H3 G34 DHG中的趋势和潜在的未来研究方向.
- 分析最被引用的出版物的图书统计特征.
主要方法:
- 确定了114篇关于H3 G34 DHG的出版物.
- 分类出版物为基础科学 (BSc),临床 (CL) 和评论 (R) 类型.
- 根据引用号和分析的文献参数对文章进行排名.
主要成果:
- 来自15个国家的文章,在2012-2024年期间发表在63个期刊上.
- 中位引用数为20个,中位数为9个作者,出版年为2020年.
- 最多引用的前十篇文章都是基础科学 (BSc) 报告,发表在影响因子较高的期刊上,而不是CL或R文章.
结论:
- H3 G34 DHG出版物的文献计量参数显示变化.
- 显而易见的是,缺乏具有重大影响力的,高度引用的临床 (CL) 报告.
- 存在着一个尚未满足的需求,即将基础科学机制与新型治疗策略的临床数据相结合.
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