在微生物中的生物生物合成和生物技术生产方面的进展
Jia-Run Zhao1,2, Si-Qi Zuo1,2, Feng Xiao1,2,3
1Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
World journal of microbiology & biotechnology
|April 13, 2024
概括
本综述探讨了微生物新生生物素 (维生素B7) 合成途径和调节系统. 它详细介绍了代谢工程和流程优化等战略,以实现可持续的大规模生物生物生产.
科学领域:
- 生物技术是生物技术.
- 代谢工程是代谢工程.
- 微生物学 微生物学
背景情况:
- 生物素 (维生素B7) 对于人类和动物的新陈代谢至关重要,在关键的代谢途径中起到辅助作用.
- 虽然植物和微生物可以合成新的生物素,但人类和动物需要通过饮食摄入.
- 目前的商业生物生产依赖于化学合成,但微生物生物生产提供了一个可持续的替代方案.
研究的目的:
- 提供对微生物新生生物素合成途径的全面概述.
- 讨论生物生产中涉及的监管和运输系统.
- 探索用于工业应用的增强微生物生物生产的策略.
主要方法:
- 关于微生物生物合成途径的科学文献的综述.
- 对生物生产微生物中的调节和传输机制的分析.
- 汇编了改善生物素产量的各种策略,包括遗传和工艺工程.
主要成果:
- 对各种微生物物种中新生生物素合成途径的详细见解.
- 确定影响生物生产的关键监管和运输系统.
- 简要介绍了提升生物素生产的先进策略,如突变育种和代谢工程.
结论:
- 微生物新生生物素合成为化学生产提供了一个可持续的替代方案.
- 代谢工程和过程优化对于有效的工业规模生物生物制造至关重要.
- 对微生物系统的进一步研究可以解锁可持续生物供应的新策略.
更多相关视频
06:24Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
10.0K
12:03Expression, Isolation, and Purification of Soluble and Insoluble Biotinylated Proteins for Nerve Tissue Regeneration
Published on: January 22, 2014
33.6K
相关概念视频
The Central Dogma
21.7K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
21.7K
Plant Breeding and Biotechnology
18.9K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
18.9K
Recombinant DNA
94.3K
Overview
94.3K
Synthetic Biology
4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
4.7K
Bioremediation
18.3K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.3K
Transgenic Plants
7.2K
Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
7.2K
