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血小板-淋巴细胞比作为小肠癌中淋巴结转移的预测因素
Xihao Chen1,2, Zhiyu Liu1,2, Jiawei Song1,2
1Xi'an Medical University, Xi'an, 710068, China.
Journal of robotic surgery
|April 13, 2024
概括
术前系统性炎症指数,如血小板-淋巴细胞比率 (PLR),可以预测小肠癌患者的淋巴结转移. 升高的PLR是淋巴结转移 (LNM) 的独立风险因素.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道手术 胃肠道手术
背景情况:
- 小肠癌 (SBC) 淋巴结转移 (LNM) 影响预后.
- 识别LNM的预测标记对于治疗规划至关重要.
研究的目的:
- 评估手术前系统性炎症指数对SBC患者中LNM的预测值.
- 在SBC中开发LNM的预测模型.
主要方法:
- 对140名接受手术的SBC患者的回顾性分析 (2010年1月至2021年6月).
- 术前炎症指数和临床数据的比较,用和没有LNM的患者之间的临床数据.
- 多因素物流回归和使用R软件构建名ogram.
主要成果:
- 单变量分析显示了炎症指数和LNM之间的关联.
- 性别,PLR,淋巴结解剖数和淋巴血管入侵是LNM的独立预测因素.
- 诺米图实现了0.855的C指数,表明了良好的预测准确性.
结论:
- 手术前的全身炎症指数,特别是PLR,是SBC中LNM的有价值预测指标.
- 纳米图包括临床因素和PLR可以帮助预测LNM风险.
- 升高的PLR是小肠癌中LNM的一个独立风险因素.
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