微生物群驱动着在压力下肠道的托代谢中的白天节律
Cassandra E Gheorghe1, Sarah-Jane Leigh1, Gabriel S S Tofani2
1APC Microbiome Ireland, University College Cork, T12 CY82 Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, T12 CY82 Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, T12 CY82 Cork, Ireland.
Cell reports
|April 13, 2024
概括
急性压力会影响肠道微生物群和酸盐代谢,影响因一天中的时间而异. 这突出了微生物组.
科学领域:
- 微生物组-肠道-大脑轴
- 胃肠道生理学 胃肠道生理学
- 压力反应应对压力.
背景情况:
- 慢性压力会破坏微生物群-肠-大脑轴,影响酸盐代谢,肠道屏障功能和白天节律.
- 对于急性压力对肠道的影响和日间影响的理解有限.
研究的目的:
- 研究微生物群依赖的托代谢振荡如何影响肠道屏障功能.
- 检查急性压力对小鼠肠道屏障功能和托代谢的影响.
主要方法:
- 使用无细菌和缺乏抗生素的小鼠模型.
- 进行了脑内代谢分析,以确定应激反应的代谢途径.
- 采用枪支元基因组学来分析细菌物种及其代谢功能.
主要成果:
- 托代谢是对15分钟的急性压力因素最有反应的途径.
- 通过转基因组学识别的节律性细菌物种主要是代谢托.
- 在大肠中观察到压力诱导的功能性改变,大肠中改变了酸盐代谢.
结论:
- 胃肠道对急性压力的反应受到白天的时间和肠道微生物组合的显著影响.
- 微生物群依赖的酸盐代谢在调解肠道对急性压力的反应中起着至关重要的作用.
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