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年龄和衰老过程改变了肠道微生物.

Qu Zhanbo1,2,3, Zhuang Jing1,2,3, Han Shugao4

  • 1Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou 313000, Zhejiang, China.

Aging
|April 13, 2024
PubMed
概括

随着年龄的增长,人们的肠道微生物组成发生变化,特定的细菌增加或减少. 肠道细菌的这些变化可能与与年龄相关的疾病有关.

关键词:
年龄的年龄年龄的年龄.生物信息学分析分析功能性基因是指功能性基因.肠道微生物 肠道微生物大基因组测序的测序.

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科学领域:

  • 微生物学 微生物学
  • 老年学是一门学科.
  • 人类健康 人类健康 人类健康

背景情况:

  • 肠道微生物和衰老是影响疾病发展的关键因素.
  • 肠道微生物群落的组成明显受到衰老过程的影响.

研究的目的:

  • 在45岁以上的个体中分析时间依赖的肠道微生物概况.
  • 为了研究衰老和肠道微生物组成之间的相关性.

主要方法:

  • 分析了来自510名45岁以上健康个体的便样本.
  • 使用多样性指数 (Shannon,Simpson,Ace) 和β多样性分析 (NMDS) 进行肠道微生物评估.
  • 采用随机森林 (RF) 和线性差异分析 (LDA) 来识别特征性微生物及其丰度随年龄的变化.

主要成果:

  • 45-49岁的个体表现出最高的肠道细菌丰富度.
  • 确定了15种特征性肠道微生物,包括Siphoviridae和Bifidobacterium breve.
  • 观察到与年龄相关的微生物丰富性的变化:Ligiactobacillus和Microviridae在65岁以上的人群中增加,而Blautia_A massiliensis,Lubbockvirus和Enterocloster clostridioformis则减少,Klebsiella variicola和Prevotella增加.

结论:

  • 不同的肠道微生物特征与不同的年龄组有关.
  • 肠道微生物社区结构的改变可能在与年龄相关的疾病中起作用.