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阻塞性睡眠呼吸暂停的儿童中大脑白质网络拓和认知的改变

Fangfang Chen¹, Yuchuan Fu¹, Biqiu Tang²

¹Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, China; Wenzhou Key Laboratory of Structural and Functional Imaging, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

|April 13, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 改变儿童大脑白质网络,影响认知功能. 网络变化,特别是在叶,调解了OSA严重程度和口语理解缺陷之间的联系.

科学领域:

神经科学是一个神经科学.
儿科睡眠医学儿科睡眠医学
脑部成像脑部成像

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为是一种影响儿童神经发育的疾病.
在患有OSA的儿童中,认知障碍,特别是执行功能和语言能力,是常见的.
与OSA相关的认知缺陷背后的精确神经机制仍然不完全理解.

研究的目的:

研究被诊断患有OSA的儿童大脑白质网络拓学的变化.
探索OSA的严重程度,白质网络属性和认知表现之间的关系.
阐明白质网络特征在OSA和认知障碍之间的关联中的调解作用.

主要方法:

利用图形理论分析了46名患有OSA和31名对照儿童的白质网络拓性质.
所有参与者都接受了磁共振成像 (MRI),多睡眠学和综合认知测试.
层次线性回归和调解分析检查了阻塞性呼吸暂停-呼吸暂停指数 (OAHI) 和网络属性的对认知的影响.

主要成果:

与非OSA对照组相比,患有OSA的儿童表现出明显更高的网络分类能力.
OAHI与特定大脑区域的节点性质有关,特别是在额叶和叶内.
调解分析显示,上旋右极的聚类系数将OAHI与口语理解指数联系起来.

结论:

OSA显著影响小儿大脑中白质网络的发育轨迹.
白质网络属性起到调解作用,解释了OSA严重程度 (OAHI) 和语言理解障碍之间的关系.
这些发现为患有OSA的儿童的认知功能障碍提供了关键的神经成像证据,突出了潜在的治疗点.

关键词:

孩子孩子孩子孩子认知认知能力认知能力这就是为什么MRI是MRI.阻塞性睡眠呼吸暂停症是什么白色物质网络是白色物质网络.

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