阻断胎盘多态核核髓蛋白衍生的抑制细胞中的OLFM4/甲蛋白-3轴会触发新生儿的肠道炎症
Shuaijun Lv1, Meiqi Chen2, Zhongjun Li3
1Pediatric Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
International immunopharmacology
|April 13, 2024
概括
被称为PMN-MDSCs的胎盘细胞调节胎儿生长,并可能预防死角性肠球炎 (NEC). 在胎儿生长限制 (FGR) 期间,这些细胞中的Olfm4减少会增加新生儿NEC风险.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 新生儿医学 新生儿医学
背景情况:
- 胎儿生长限制 (FGR) 与新生儿死性肠球炎 (NEC) 的风险增加有关,但潜在的机制尚不清楚.
- 胎盘多态核核髓原抑制细胞 (PMN-MDSCs) 在胎儿发育和新生儿肠道炎症中发挥作用.
研究的目的:
- 调查胎盘PMN-MDSCs,FGR和NEC之间的相关性.
- 阐明 olfactomedin-4 (Olfm4) 基因在胎盘 PMN-MDSCs 在胎儿发育过程中的作用及其对 NEC 易感性的影响.
主要方法:
- 对怀孕和非怀孕个体的胎盘PMN-MDSC和Olfm4表达的分析.
- 利用在骨髓细胞中缺乏Olfm4的小鼠模型来研究FGR,胎盘PMN-MDSC和后代的NEC易感性.
- 研究了涉及加勒-3 (Gal-3),OLFM4,增长促进因子 (GPF) 和缺氧诱导因子-1α (HIF-1α) 的调节途径.
主要成果:
- 在怀孕晚期,胎盘PMN-MDSC和Olfm4表达升高.
- 缺乏骨髓质Olfm4的小鼠表现出FGR,降低了胎盘PMN-MDSC,降低了GPF分泌,导致后代易受肠道炎症和NEC的影响.
- Gal-3通过HIF-1α刺激了OLFM4介导的GPF分泌;FGR胎盘中的OLFM4减少与更高的新生儿发病率相关.
结论:
- 胎盘PMN-MDSC对胎儿发育和减轻新生儿肠道炎症至关重要.
- 胎盘PMN-MDSC中的OLFM4介导途径对于预防NEC至关重要,而其在FGR中的下调有助于新生儿发病率.
相关概念视频
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
01:22Development of Immunocompetence
305
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
305
01:23Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K