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在SHIP抑制中介选择TREM2诱导的微质功能

Gautham S Ramakrishnan1, William L Berry2, Angela Pacherille3

  • 1Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Molecular immunology
|April 13, 2024
PubMed
概括

在骨髓细胞表达的触发受体2 (TREM2) 对阿尔茨海默病 (AD) 中的微质神经保护至关重要. 这项研究表明,含SH2的异醇-5'-酸酶1 (SHIP1) 对TREM2功能有负面调节,从而提供了治疗见解.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.微质细胞中的微质细胞发细胞症 (phagocytosis) 是一种致死细胞的发生.这是一种SHIP抑制剂.飞船1号 飞船1号在TREM2中,我们可以使用TREM2.

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