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光生物调节治疗对多发性硬化症患者肌肉功能的影响
Mitra Rouhani1, Miguel Tolentino2, Jeri-Anne Lyons2
1Exercise and Rehabilitation Science program, Department of Physical Therapy, College of Health Sciences, Marquette University, 1250 West Wisconsin Ave, Milwaukee, WI 53233, USA.
Multiple sclerosis and related disorders
|April 13, 2024
概括
光生物调节疗法 (PBMT) 可以改善多发性硬化症 (pwMS) 患者的肌肉强度和力量恢复. 这种低级激光疗法显示出作为一种新的治疗方法来提高 pwMS 肌肉性能的潜力.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 肌肉疲劳和软弱在患有多发性硬化症 (pwMS) 的人群中很普遍,影响日常活动.
- 已知光生物调节疗法 (PBMT),一种使用光 (600-1100 nm) 的低级激光疗法 (LLLT),可以提高健康个体的肌肉性能,可能是通过改善线粒体功能.
- 在pwMS中,PBMT对肌肉性能的潜在益处需要进行调查.
研究的目的:
- 评估PBMT对多发性硬化症 (pwMS) 患者肌肉性能的短期和长期影响.
- 确定最佳的PBMT剂量,以改善 pwMS 肌肉功能.
主要方法:
- 一个随机的双盲交叉研究,涉及门诊 pwMS (N=17).
- 研究I评估肌肉功能 (最大自愿收缩,肌肉疲劳) 在PBMT前后在不同能量剂量 (40J,80J,120J) 或安慰剂下.
- 第二项研究涉及一个小组 (N=12),该小组接受了两个星期的个性化PBMT剂量,并重新评估了肌肉功能.
主要成果:
- 在研究I中,高剂量的PBMT显著改善了力量恢复 (101.89%对比96.3%的安慰剂,p=0.03).
- 在研究II中,与基线和安慰剂相比,活跃的PBMT显著增强了肌肉力量 (平均变化为22.87N与-4.12N,p=0.02).
- 在这两项研究中,PBMT并没有显著改善肌肉疲劳或耐力时间.
结论:
- 个性化PBMT剂量可以增强轻度至中度多发性硬化症患者的肌肉力量恢复和力量.
- PBMT提供了一个潜在的新疗法选择,单独或与其他治疗相结合,用于提高 pwMS 肌肉性能.
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