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Updated: May 3, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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基于多维理性设计的 Echinocandin B 脱酶的疏水基质结合口袋改造

Heng Tang1, Han-Yue Zhu1, Yin-Feng Huang1

  • 1National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China.

International journal of biological macromolecules
|April 13, 2024
PubMed
概括

酶工程显著提高了Actinoplanes utahensis deacylase (AAC) 对抗真菌合成的活性. 量身定制基质结合口袋提高了催化效率,使得安尼杜拉金生产的产品转化率更高.

关键词:
结合能量是有约束力的.绑定的口袋绑定的口袋脱酶是一种脱酶.水性分析的分析.分子动力学模拟模型多维的合理设计多维的合理设计.基质的范围包括:

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