在韩国,长期暴露于空气污染和过早的青春期
Jongmin Oh1, Jung Eun Choi2, Rosie Lee2
1Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Institute of Ewha-SCL for Environmental Health (IESEH), College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Department of Human Systems Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea; Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Republic of Korea.
Environmental research
|April 13, 2024
概括
长期暴露于空气污染,包括细颗粒物 (PM2.5) 和臭氧,与女孩早期青春期 (PP) 的风险增加有关. 减少空气污染对儿童健康至关重要.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 流行病学 流行病学
背景情况:
- 过早的青春期 (PP) 是一个日益严重的全球性问题,对空气污染的作用的研究有限.
- 调查韩国长期空气污染暴露与PP发病之间的关联.
研究的目的:
- 检查暴露于特定空气污染物和早期青春期发展之间的关系.
- 识别可能导致青春期早期发育的环境风险因素.
主要方法:
- 使用韩国国家医疗保险数据库 (2013-2015) 进行的回顾性队列研究.
- 包括1,205,784名被诊断患有PP的六岁儿童,并接受过性腺激素释放激素激动剂治疗.
- 考克斯的比例危险模型评估了空气污染物 (PM2.5,PM10,SO2,NO2,O3) 和PP发病之间的关联.
主要成果:
- 在女孩中,PM2.5,PM10,SO2和O3暴露与PP之间观察到积极的关联.
- 危害比率表明,在女孩中这些污染物含量较高时,PP风险增加.
- 在空气污染暴露和男孩的PP之间没有发现显著的关联.
结论:
- 空气污染被确定为女孩早期青春期的重要危险因素.
- 研究结果强调了空气污染对儿童和青少年发育的有害影响.
- 强调需要战略来管理和减少空气污染的公共卫生利益.
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