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对衰老相关基因的综合性分析确定了肝细胞癌中具有独特特征的强大的预后集群

Sicheng Liu¹, Yang Meng¹, Yaguang Zhang¹

¹Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.

Journal of advanced research

|April 13, 2024

概括

这项研究揭示了肝细胞癌 (HCC) 中的三个与衰老相关的基因集群,确定了患者分层的潜在治疗标和生物标志物. 高衰老与免疫抑制和HCC中药物敏感性相关.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
生物信息学是一种生物信息学.

背景情况:

细胞衰老,一种永久性细胞循环停止的状态,悖论地促进癌症的进展,尽管它的瘤抑制起源.
了解衰老在癌症中的作用受到缺乏特定标记物来量化衰老水平的阻碍.
肝细胞癌 (HCC) 的进展受细胞衰老的影响,需要对其机制进行更深入的研究.

研究的目的:

通过整合性分析,研究与衰老相关的基因 (SRG) 在肝细胞癌 (HCC) 中的作用.
根据老化概况对HCC患者进行分层,以实现个性化治疗策略.
确定与HCC老化相关的新生物标志物和治疗点.

主要方法:

基于SRG的HCC患者的共识聚类.
计算分析包括ssGSEA和模糊的c-means算法.
在体和体外验证使用qRT-PCR,西部斑点和共同培养系统.

主要成果:

确定了三种不同的HCC患者的预后集群,其生存,突变和免疫概况各不相同.
开发了一种衰老评分系统,用于HCC的批量和单细胞衰老概况.
证实了衰老诱导的干部重编程,并确定MAFG是免疫抑制,衰老和HCC中的干部的关键调解者.

结论:

与衰老相关的基因在HCC患者分层中发挥着关键作用.
这项研究为基于老化水平的HCC精准医学方法提供了一个框架.
对与衰老相关的HCC亚型确定了潜在的治疗药物,包括Tozasertib.

关键词:

计算方法计算方法肝细胞癌是肝细胞癌.预测集群的预测集群与衰老相关的干性.与衰老相关的基因与衰老有关.治疗策略治疗策略

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