尿中的酸度和女性甲状腺功能:TREE研究的结果
Yang Wu1, Yan-Ling Deng1, Min Zhang1
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
The Science of the total environment
|April 13, 2024
概括
暴露于消毒副产品 (DBPs),特别是酸 (HAAs),与接受辅助生殖技术 (ART) 的妇女的甲状腺激素干扰有关. 这项研究强调了HAA对甲状腺功能的潜在风险.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 生殖科学 生殖科学
背景情况:
- 消毒副产品 (DBPs) 是环境污染物,在实验模型中与甲状腺功能受损有关.
- 关于DBP对人类甲状腺功能的影响的流行病学证据仍然有限.
研究的目的:
- 调查暴露于特定DBPs,即二乙酸 (DCAA) 和三乙酸 (TCAA) 和甲状腺功能指标之间的关联.
- 在接受辅助生殖技术 (ART) 的妇女中评估甲状腺激素平衡.
主要方法:
- 在1190名来自Tongji生殖和环境 (TREE) 队列的妇女中,测量了血清铁激素 (TSH),自由三铁激素 (FT3) 和自由甲状腺素 (FT4).
- 分析了DCAA和TCAA的尿度,以量化个体的DBP暴露.
- 甲状腺激素比率 (FT4/FT3和TSH/FT4) 被计算出来,以评估甲状腺激素的平衡.
主要成果:
- 尿液中TCAA度较高与血清TSH和TSH/FT4比率升高,血清FT3和FT4水平降低有关.
- 尿液中DCAA度的增加与FT4/FT3比率有负相关性.
- 使用限制立方线和通用添加模型证实了剂量反应关系.
结论:
- 尿液中的酸 (HAA) 与接受ART的女性甲状腺激素平衡的改变有关.
- 这些发现表明,常见的DBPs对脆弱人群中的甲状腺功能有潜在的内分泌干扰作用.
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