德克萨米他对手术后血糖控制在初级关节整形术后的患者的影响:一项随机双盲对照试验
Xiao-Yang Liu1, Ping Mou2, Jian Cao1
1Department of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
The Journal of arthroplasty
|April 13, 2024
概括
在全关节关节整形手术前给出的甲 (DEX) 可以在非糖尿病患者中暂时增加血糖 (BG). 血糖化血红蛋白A1c水平升高是手术后血红蛋白升高的危险因素.
科学领域:
- 麻醉学 麻醉学
- 内分泌学 在内分泌学.
- 整形外科手术 整形外科手术
背景情况:
- 在全关节整形术 (TJA) 中使用甲 (DEX) 可能导致外科手术期间血糖 (BG) 障碍.
- 这些BG疾病可能会导致非糖尿病患者的并发症.
研究的目的:
- 评估不同剂量的DEX对非糖尿病患者经过TJA的术后BG水平的影响.
- 为了确定术后BG水平升高的危险因素.
主要方法:
- 135名非糖尿病患者被随机分为三个组:安慰剂 (盐水),10毫克DEX IV或20毫克DEX IV.
- 主要结局:术后禁食BG (FBG). 二次结局:术后的食后BG (PBG).
- 研究了BG升高 (FBG≥140 mg/dL,PBG≥180 mg/dL) 的并发症和危险因素.
主要成果:
- 在手术后的0日和1日,DEX组 (B和C) 的FBG水平高于安慰剂组 (A).
- 与术后第一天的C组相比,A和B组的PBG水平较低.
- 在术后第一天之后,没有观察到BG或并发症的显著差异.
- 手术前血糖化血红蛋白A1c (HbA1c) 升高增加了FBG和PBG升高的风险.
结论:
- 术前IVDEX (10或20毫克) 在TJA后对非糖尿病患者的术后BG有暂时的影响.
- 在手术前的HbA1c水平为5.75% (FBG) 和5.85% (PBG) 是BG风险增加的门,无论DEX的使用或剂量如何.
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