开发一个核心结果集,用于评估在初级保健中长期处方药的成年人的药物坚持干预措施
Debi Bhattacharya1, Kumud Kantilal1, Jacqueline Martin-Kerry1
1School of Healthcare, University of Leicester, Leicester, UK.
Research in social & administrative pharmacy : RSAP
|April 13, 2024
概括
一个核心结果集 (COS) 已开发,以标准化初级保健中的药物坚持性试验. 该套件确保对生活质量和药物持续性等关键结果的一致报告.
科学领域:
- 医疗保健服务研究 医疗服务研究
- 临床试验方法论 临床试验方法论
- 患者坚持性研究
背景情况:
- 药物不服药影响了大约一半的患者,这表明初级保健中的关键差距.
- 现有的研究缺乏对评估药物坚持干预措施的基本结果的共识.
研究的目的:
- 为初级保健试验建立一个核心结果集 (COS),专注于药物坚持干预.
- 目标人群包括患有需要处方药的长期疾病的成年人.
主要方法:
- 从现有文献中编制了一个全面的结果列表.
- 进行了两轮的Delphi调查,涉及患者,护理人员,初级保健工作人员和研究人员.
- 为了完成COS,举行了共识研讨会,考虑结果测量的重要性,可行性和可接受性.
主要成果:
- 150名参与者在德尔菲第一轮,101名在第二轮; 8名参与者在共识研讨会.
- 确定了七个关键结果:与健康相关的生活质量,服用剂量,药物持续性,药物开始,干预相关性,死亡率和不良药物事件.
结论:
- 开发的COS为初级保健药物坚持性试验提供了一套标准化的最低结果.
- 可行性和可接受性是COS开发过程的核心.
- 除了这个核心集合之外的试验可以包括额外的特定背景结果.
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