肺功能与呼吸障碍之间的关联及其在跨国阻塞性肺病负担研究 (BOLD) 中的变化
A Müller1,2, E F Wouters1,3,4, P Koul5
1Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
Pulmonology
|April 13, 2024
概括
呼吸障碍的患病率在全球范围内有所不同,并且与肺功能减弱有关. 这项研究强调了在研究中讨论修改后的医学研究委员会 (mMRC) 呼吸障碍尺度的必要性.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 全球健康 全球健康
背景情况:
- 呼吸不良 (呼吸短促) 是一个常见的呼吸道症状.
- 关于其全球患病率和与肺功能相关的数据有限,特别是在低收入和中等收入国家.
- 这项研究解决了这些知识差距.
研究的目的:
- 为了估计呼吸障碍的全球患病率.
- 在不同的人群中调查呼吸障碍和肺功能之间的关联.
- 为呼吸系统健康研究和临床实践提供信息.
主要方法:
- 利用了25806名成年参与者在跨国阻塞性肺病负担研究中的数据.
- 使用医学研究理事会 (mMRC) 修改的呼吸障碍尺度 (≥2) 评估呼吸障碍.
- 采用多变量逻辑回归和随机效应元分析来检查与螺旋计定义的肺功能障碍的关联.
主要成果:
- 呼吸障碍的患病率在全球范围内有很大差异,平均为13.7%,从0%到28.8%不等.
- 在呼吸障碍和限制性肺功能 (OR 2.07) 和气流阻塞 (OR 3.76) 之间发现了强烈的关联.
- 这些关联在性别,年龄组和吸烟史中都是一致的,尽管在肥胖个体中较弱.
结论:
- 全球呼吸障碍的患病率很大,并且在地理上有很大的差异.
- 呼吸不良是肺功能受损的重要指标,包括限制和阻塞.
- 在流行病学研究中使用mMRC尺度的实用性和应用需要进一步讨论.
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