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Updated: Jul 22, 2026

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
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Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

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空间和单细胞同位素分析揭示了MDK介导的免疫抑制环境与调节性T细胞在结直肠癌发生过程中的结直肠癌

Masahiro Hashimoto1, Yasuhiro Kojima2, Takeharu Sakamoto3

  • 1Department of Surgery, Kyushu University Beppu Hospital, Beppu, 874-0838, Japan; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.

EBioMedicine
|April 13, 2024
PubMed
概括

从结直肠癌 (CRC) 细胞向调节性T细胞 (Tregs) 传递的中基因 (MDK) 信号驱动瘤免疫抑制. 针对MDK/syndecan4 (SDC4) 途径可能为早期CRC诊断和治疗提供新的策略.

关键词:
结肠直肠癌是一种癌症.免疫耐受性是一种免疫耐受性.这是MDK MDK.在SDC4中,它是SDC4.单细胞RNA测序的一个细胞.空间转录组学 空间转录组学

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Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment06:05

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...