患有PCOS的女性的肠道细菌组和情绪障碍
S Lee1,2, M V Tejesvi3,4, E Hurskainen1
1Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Human reproduction (Oxford, England)
|April 13, 2024
概括
患有多囊卵巢综合征 (PCOS) 和情绪障碍 (MDs) 的女性表现出改变的肠道细菌,其多样性较低,有益细菌较少. 这种肠道微生物群的差异与PCOS有关,无论情绪障碍状态如何.
科学领域:
- 微生物组研究的研究.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 多囊卵巢综合征 (PCOS) 增加了女性情绪障碍 (MDs) 的风险.
- 肠道微生物组与PCOS和MD的病理生理学有关.
研究的目的:
- 为了研究PCOS和情绪障碍 (MDs) 患者与仅PCOS患者之间的肠道细菌群的差异.
- 探索肠道细菌组对PCOS和MDs之间的关联的贡献.
主要方法:
- 一个基于人口的队列研究,使用北芬兰出生队列1966年.
- 来自102名患有PCOS的女性和205名BMI匹配的对照的便样本的16S rRNA测序.
- 对肠道细菌组多样性和组成的分析,与临床特征相关.
主要成果:
- 与没有MD的PCOS妇女相比,患有PCOS和MD的妇女的肠道细菌组α多样性减少,Butyricicoccus的丰度较低.
- 与MDs相关的肠道细菌组变化不论PCOS状态都被观察到.
- 在PCOS组中,特定的细菌 (Sutterella) 与肥胖,葡萄糖代谢和肠道屏障完整性标记相关.
结论:
- 肠道细菌组与MDs相关,独立于PCOS.
- PCOS可能进一步调节肠道细菌组与MDs的连接.
- 这些发现表明肠道微生物组在PCOS和MDs的并发症中可能发挥作用.
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