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人和老鼠的急性脊髓损伤血清生物标志物:一个覆盖范围的系统审查

Sina Shool1,2, Saeed Rahmani1, Mohammad Amin Habibi1,2

  • 1Department of Neurosurgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Spinal cord series and cases
|April 13, 2024
PubMed
概括

本综述确定了脑脊液 (CSF) 和血清生物标志物,用于评估人类和老鼠模型中脊髓损伤 (SCI) 的严重程度. 生物标志物模式表明了监测SCI进展和结果的潜力.

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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