沙特儿童功能性便秘的临床概况
Mohammad El Mouzan1, Mohammed Kambal1, Hayfa Alabdulkarim1
1From the Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia.
聚乙烯甘醇 (PEG) 在治疗沙特儿童功能性便秘方面比乳糖更有效,更能耐受. 遵守治疗是儿童功能性便秘管理中积极临床反应的关键.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床药理学 临床药理学
背景情况:
- 功能性便秘 (FC) 在儿童中很普遍.
- 沙特儿科人口中FC临床特征的数据有限.
研究的目的:
- 描述沙特儿童功能性便秘的临床特征.
- 为了比较聚乙烯糖醇 (PEG) 与乳糖在FC管理中的有效性和耐受性.
主要方法:
- 追溯研究包括370名沙特儿童被诊断患有FC (罗马标准IV).
- 收集了人口统计,临床特征和治疗反应的数据.
- 统计分析使用了描述性统计和皮尔森的千平方测试.
主要成果:
- 发病的中位数年龄为4岁;14%的患者年龄在一年以下.
- 腹部疼痛是最常见的相关症状 (44%).
- 与乳糖相比,聚乙烯糖醇 (PEG) 的耐受性 (P=.0008) 和有效性 (P<.0001) 显著提高.
结论:
- 聚乙烯甘醇 (PEG) 建议作为沙特儿童功能性便秘的第一线治疗.
- 治疗顺应性成为临床反应的唯一显著预测因素.
- 进一步的前性研究是有必要的,以探索不合规因素.
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