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与对照组相比,鉴定了COVID-19患者血清中的一些可变参数

Ebtihal C Abbas¹, Mais M Salim¹, Ahmed C Abbas²

¹Department of Pathology and Forensic Medicine, Faculty of Medicine University of Kufa, Kufa, Iraq.

The Egyptian journal of immunology

|April 14, 2024

概括

冠状病毒疾病2019 (COVID-19) 感染显著影响肝功能测试,脂质资料和甲状腺激素. 在COVID-19患者中,肝酶,胆固醇,甘油三和甲状腺抗体的增加.

科学领域:

内分泌学在内分泌学.
肝病学肝病学是一种肝病学.
病毒学病毒学

背景情况:

冠状病毒疾病2019 (COVID-19) 是一种具有多样化临床表现的全球性流行病.
新出现的证据表明,可能涉及多个器官,包括肝脏和甲状腺.

研究的目的:

调查COVID-19感染与肝功能测试 (LFT),脂质资料和甲状腺激素异常之间的相关性.
评估COVID-19对关键代谢和内分泌标记物的影响.

主要方法:

一项包括160名COVID-19患者和100名健康对照在伊拉克纳贾夫的队列研究.
对肝酶 (ALT,AST,ALP,albumin),脂质特征 (总胆固醇,LDL,三糖化物),甲状腺激素 (T3,T4,TSH) 和抗甲状腺抗体的分析.

主要成果:

在COVID-19患者 (p <0.05) 中观察到肝酶 (ALT,AST,ALP,albumin) 和脂质 (总胆固醇,LDL,甘油三) 的显著升高.
在受感染的人群中,甲状腺激素 (T3,T4,TSH) 和抗甲状腺抗体 (TgAb,TPOAb,TRAb) 的增加显著差异.
在甲状腺激素/抗体升高和COVID-19感染之间发现了积极的相关性.

结论:

COVID-19 感染与肝功能显著障碍有关.
该研究表明,COVID-19可以诱导脂质代谢和甲状腺功能的改变,包括增加甲状腺抗体.

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