在固体瘤的抗瘤全身治疗期间,失血症会增加死亡和其他副作用的风险:一项横截面研究
P-G Silva1, G-A Barreto, A-C Carlos
1Ceará Cancer Institute Laboratory of Molecular Biology and Oncogenetics Papi Júnior Street, 1222, Rodolfo Teófilo 60351-010, Fortaleza, Ceará, Brazil paulo_goberlanio@yahoo.com.br.
Medicina oral, patologia oral y cirugia bucal
|April 14, 2024
概括
改变口味 (失味症) 影响超过一半接受化疗 (CT) 的患者. 这种常见的副作用增加了其他不良事件的风险,并对患者的生存结果产生了负面影响.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
- 患者护理 患者护理
背景情况:
- 化疗 (CT) 是癌症治疗的基石,但会引起显著的不良影响.
- 改变口味 (失味症) 是一种常见的CT诱导的副作用,与营养不良和其他胃肠道问题有关.
- 抗凝血症对化疗副作用和患者存活率的影响仍然不完全理解.
研究的目的:
- 为了研究在抗瘤化疗期间的异质症和其他不良反应之间的关联.
- 为了评估dysgeusia对接受化疗的患者的整体生存时间的影响.
- 为了确定与异质症发生相关的临床因素.
主要方法:
- 一项观察性,回顾性,横截面研究分析了来自5744名患者的数据.
- 使用CTCAE v5.0尺度,在化疗课程之前评估了不良反应,包括痛症.
- 使用统计分析,包括奇平方和曼特尔-科克斯日志等级测试,以确定关联.
主要成果:
- 50.6%的患者患有松症,与女性性别,超重,晚期瘤阶段和联合辅助/非辅助疗法有关.
- 腹症与腹,厌食症,口腔粘膜炎,恶心,便秘和吐有显著的积极关联.
- 在dysgeusia和疲劳之间发现了一个显著的反向关联,而在四年生存期观察到一个积极的关联.
结论:
- 失血症是化疗常见的副作用,具有重大临床影响.
- 缺血症的存在与其他多种化疗相关不良反应的发病率增加有关.
- 失血症在抗瘤化疗期间会对患者的预后和整体存活率产生负面影响.
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