在全膝关节整形术中影响周围假肢骨矿物质密度的因素:系统性审查
Haojing Zhou1, Lei Chen1, Hai Su1
1Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Archives of orthopaedic and trauma surgery
|April 14, 2024
概括
在全膝关节整形术 (TKA) 后优化周围假肢骨矿物质密度 (BMD) 需要考虑假肢类型,茎设计和患者体重. 这些因素对于预防并发症和改善TKA后的康复至关重要.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学 生物材料科学
- 放射学 放射学是一门学科.
背景情况:
- 膝关节全关节整形术 (TKA) 可能导致周围假肢骨矿物质密度 (BMD) 降低.
- 这种下降可能会导致诸如假肢松动和骨折等并发症,影响恢复.
- 了解影响周围假肢骨损伤的因素对于TKA结局至关重要.
研究的目的:
- 系统地审查和总结影响TKA后周围假肢BMD的因素.
- 确定可优化以改善膝关节植入物周围骨健康的关键元素.
主要方法:
- 在四个主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了系统的搜索.
- 关键词包括"全膝关节整形术"",骨矿物质密度"",骨"和"股骨".
- 审查了2001年至2023年间发表的文章.
主要成果:
- 从1391篇最初的文章中,包括了22项研究.
- 六个类别显著影响周围假肢骨:假肢类型,茎设计,涂层,体重,使用水泥和钉距离.
- 诸如移动轴承假肢,化涂层和更高的BMI等特定因素与更好的BMD有关.
结论:
- 移动轴承假肢,模块化聚乙烯,短/十字形茎,避免水泥,更高的BMI,化涂层和较小的中间距离可能会增强周围假肢的BMD.
- 术前对这些因素的考虑和术后的药物治疗对于优化BMD至关重要.
- 进一步的研究和这些发现的临床应用可以改善TKA患者的治疗结果.
相关概念视频
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K


