克洛斯特里迪奥伊德困难感染在非常老年人的临床结局
Sameer Kassem1, Nizar Hijazi2, Nili Stein3
1Department of Internal Medicine, Lady Davis Carmel Medical Centre, The Ruth and Bruce Rappaport Medical School, Technion Israel Institute of Technology, Michal 7, 3436212, Haifa, Israel. sameerkassem@gmail.com.
Internal and emergency medicine
|April 14, 2024
概括
患有Clostridioides difficile感染 (CDI) 的非常老年患者的住院时间更短,重症监护室的入院次数更少. 他们的结果,包括死亡率,与年轻的老年患者相似,这表明年龄本身并不决定预后.
科学领域:
- 传染性疾病 传染性疾病
- 老年医学 老年医学
- 临床结果研究研究
背景情况:
- 艰难杆菌感染 (CDI) 具有显著的发病率,死亡率和经济负担.
- CDI的主要风险因素包括晚年,长期住院和抗生素暴露.
- 有限的数据存在于CDI的临床结果,特别是在非常老年患者群体.
研究的目的:
- 为了比较老年人和非常老年住院患者之间Clostridioides difficile感染 (CDI) 的临床结果.
- 评估晚年对医院住院时间,重症监护室 (ICU) 住院和CDI患者死亡率的影响.
主要方法:
- 采用了回顾性队列研究设计,分析了2016年至2018年期间住院患有CDI的患者.
- 评估了人口,临床和实验室参数.
- 关键结果包括住院时间,ICU入院,住院死亡率,出院后30天的死亡率和复合的再入院/死亡结果,比较患者年龄在80岁 (老年人) 和80岁以上 (非常老年人).
主要成果:
- 该研究包括196名患者,其中57%被归类为非常老年人 (平均年龄86岁).
- 非常老年患者的住院时间显著缩短 (13 vs. 22天,p=0.003),ICU入院率降低 (1.8% vs. 10.7%,p=0.01).
- 两组之间在住院或出院后30天的死亡率上没有发现显著差异.
结论:
- 在这个队列中,患有CDI的非常老年患者在没有增加死亡风险的情况下住院时间更短.
- 尽管ICU入院率较低,但非常老年患者的住院生存率与老年患者相似.
- 高龄本身不应该成为诊断出Clostridioides difficile感染的患者预后的主要决定因素.
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