糖尿病自主和外围神经病变中的胃肠道症状负担 - - 丹麦人队列研究
Huda Kufaishi1, Hatice Isik Mizrak1, Birgitte Brock2
1Steno Diabetes Center Copenhagen, Herlev, Denmark.
高胃肠道症状得分与1型和2型糖尿病患者的糖尿病自主神经病变 (DAN) 和远距离对称多神经病变 (DSPN) 有关. 然而,与其他神经病变测试相关的症状负担在糖尿病类型之间有所不同.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 糖尿病自主神经病变 (DAN) 和远距离对称多神经病变 (DSPN) 是糖尿病的常见并发症.
- 糖尿病患者经常报告胃肠道 (GI) 症状,但其与神经病变的关联尚未完全理解.
研究的目的:
- 调查GI症状的综合加权症状得分 (CWSS) 与1型和2型糖尿病患者的DAN和DSPN存在之间的关联.
- 将这些关联单独分析为1型和2型糖尿病.
主要方法:
- 在第三级门诊中进行了一项横截面研究.
- 用胃肠道综合症状指数 (GCSI) 和胃肠道症状评分 (GSRS) 来计算CWSS,评估了胃肠道症状.
- 使用复合自主症状评分31 (COMPASS-31),心脏自主反射测试 (CARTs),电化学皮肤导电性 (ESC),振动感知值 (VPT),密歇根州神经病学查仪器 (MNSI) 和感官测试来评估DAN和DSPN. 对相关共变量进行了调整.
主要成果:
- 该研究包括566名1型糖尿病患者和377名2型糖尿病患者.
- 在25%的1型糖尿病患者和38%的2型糖尿病患者中观察到高CWSS.
- 高CWSS与较高的DAN (通过COMPASS-31) 和DSPN (通过VPT和MNSI在1型;通过ESC,VPT和疼痛感觉在2型) 的几率显著相关. 在1型糖尿病中,高CWSS的心脏自主神经病变也更频繁.
结论:
- 胃肠道症状的高负担与糖尿病自主神经病变和远距离对称多神经病变有关,特别是当通过COMPASS-31和振动感知进行评估时.
- 胃肠道症状负担与其他神经病症措施之间的关联显示了1型和2型糖尿病之间的不一致性.
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