相关实验视频

Updated: Jun 28, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

光学控制和核向的CECR2竞争对手将对转移性乳腺癌免疫治疗的CSF-1进行下调

Yi Cen¹, Ying Chen¹, Xinxuan Li¹

¹The Fifth Affiliated Hospital, Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, the School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, PR China.

|April 14, 2024

概括

研究人员开发了一种新的光学控制药物 (N-PB),针对CECR2抑制乳腺癌中的免疫抑制细胞. 这一策略有效地抑制瘤生长,并激活了用于转移性乳腺癌治疗的抗瘤免疫力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药物发现药物发现药物发现

背景情况:

瘤相关巨细胞 (TAMs) 通过与癌细胞的交叉接触促进乳腺癌的进展和免疫抑制.
猫眼综合征染色体候选区域2 (CECR2) 在乳腺癌中过度表达,并激活核因子 κB (NF-κB) 信号,导致殖民地刺激因子-1 (CSF-1) 释放.
抑制CECR2可以降低CSF-1的调节,并减少与瘤生长相关的M2型TAM.

研究的目的:

开发一种针对CECR2-NF-κB通路的新型治疗策略,以克服转移性乳腺癌中的免疫抑制.
构建和评估一种基于化学的,光学控制的CECR2竞争者 (N-PB),用于增强药物递送和免疫细胞死亡诱导.

主要方法:

鉴定乳腺癌中CECR2过度表达及其在激活NF-κB信号传递中的作用.
开发N-PB,一种光学控制的CECR2抑制剂,用于有针对性的输送和治疗效果.
在体内评估N-PB在向乳腺癌,抑制原发性瘤和在光学辐射下调节TAM的疗效.

主要成果:

在光学辐射下,N-PB证明了有利的乳腺癌向和初级瘤抑制.
N-PB竞争性地抑制了CECR2和NF-κB (RelA) 相互作用,降低了CSF-1的调节,并减少了免疫抑制的M2类TAM.
治疗将TAM转移到一种抗瘤的M1-类表型,并激活了全身抗瘤免疫力.

结论:

切断乳腺癌细胞和TAM之间的CECR2-介导交叉声是一种可行的治疗策略.
光学控制的N-PB通过调节瘤微环境并增强抗瘤免疫力,为转移性乳腺癌治疗提供了一个有前途的方法.

关键词:

猫眼综合征染色体候选区域2 (CECR2) 候选区域殖民地刺激因子-1 (CSF-1)免疫治疗是一种免疫疗法.巨细胞是一个巨细胞.核能有针对性的交付目标

更多相关视频

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...