在老年患者中对口腔喉乱的神经生理学表征
Nicolau Guanyabens1, Noemí Tomsen2, Ernest Palomeras3
1Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de Mataró, Universitat Autónoma de Barcelona, Barcelona, Spain; Neurology Department, Hospital de Mataró, Barcelona, Spain.
概括
患有口腔喉乱症 (OD) 的老年患者表现出不安全的吞和延迟生物力学. 他们的神经生理学表明喉感觉和运动反应受损,这表明了对与衰老相关的吞障碍的新见解.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 口腔喉功能障碍 (OD) 是老年人常见和衰弱的疾病.
- 衰老与吞功能的变化有关,但与衰老相关的OD中的特定生物力学和神经生理学变化需要进一步阐明.
研究的目的:
- 在被诊断患有口腔大功能障碍 (OD) 的老年患者中全面描述吞生物力学和神经生理学.
- 为了比较OD的老年患者,老年健康志愿者和年轻健康志愿者之间的这些参数.
主要方法:
- 一项观察性研究涉及三个组:年轻的健康志愿者 (HV),老年健康志愿者 (OHV) 和老年患有OD (OOD) 的患者.
- 通过视频光学评估吞生物力学.
- 神经生理学评估使用喉感觉唤起潜能 (pSEP) 和喉运动唤起潜能 (pMEP) 通过电气和跨磁刺激 (TMS),分别.
- 使用酶相关免疫吸收试验 (ELISA) 分析的唾液神经.
主要成果:
- 显著的大多数 (83.3%) OOD 患者表现出不安全的吞,其特点是透-吸收等级得分高,喉前门关闭延迟.
- OOD患者表现出喉感觉受损,包括更高的感觉值和延迟的pSEP延迟.
- 在OOD患者中观察到皮层刺激性降低和运动反应延迟,这由两个半球中较高的喉运动值和延迟的pMEP延迟率表明.
结论:
- 老年患有OD的患者有不安全的吞,延迟的生物力学和受损的喉感觉和运动神经生理学.
- 这些发现突出了与衰老相关的OD病理生理学的新方面.
- 结果表明,有可能为患有OD的人制定更有针对性的神经康复策略.
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