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Updated: Jun 28, 2025

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A Free-breathing fMRI Method to Study Human Olfactory Function
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嗅觉功能障碍在轻度认知障碍和阿尔茨海默病中的作用:一个元分析
Jaime Bouhaben1, Alice Helena Delgado-Lima1, María Luisa Delgado-Losada1
1Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223 Pozuelo de Alarcon, Spain.
Archives of gerontology and geriatrics
|April 14, 2024
概括
嗅觉缺陷,特别是在嗅觉识别方面,在轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 中是显著的. 一个简单的气味识别测试可以帮助在风险人群中早期发现AD.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 临床心理学 临床心理学
背景情况:
- 嗅觉功能障碍越来越被认为是神经退行性疾病的早期指标.
- 轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 与感官缺陷有关,包括嗅觉受损.
- 了解MCI和AD的特定嗅觉缺陷对于早期诊断至关重要.
研究的目的:
- 进行一项元分析,调查嗅觉缺陷与轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 之间的关联.
- 在MCI和AD人群中量化嗅觉障碍的程度.
- 探索全球认知状态和嗅觉缺陷之间的关系.
主要方法:
- 通过从已识别的文章中获取的数据进行了全面的元分析.
- 研究的方法质量根据PRISMA指南进行了评估.
- 计算了对冲的g效应大小,以确定标准平均差异和置信区间;进行了调节者分析.
主要成果:
- 在MCI和AD样本中,气味识别缺陷的效果大于气味值或歧视.
- 在MCI (k = 65) 中的嗅觉识别 (OI) 评分中观察到适度的效果大小.
- 与MCI (k = 61) 相比,阿尔茨海默病 (AD) 在嗅觉识别上表现出中等到大的异质效应.
- 全球认知状态与MCI和AD的嗅觉识别障碍有积极的关系.
结论:
- 嗅觉障碍,特别是嗅觉识别障碍,在MCI中显著存在,反映了AD中所见的缺陷.
- 嗅觉识别下降是MCI的主要感官缺陷,类似于AD.
- 建议使用简单的气味识别测试来评估患有阿尔茨海默病风险的个体,作为实用的早期检测工具.
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