在第一发精神分裂症中出现的亚区域性乳头功能连接异常和认知障碍
Li-Na Wang1, Shuo Lin1, Lu Tian1
1The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
在第一个发作精神分裂症 (FES) 中存在着thalamic功能连接 (FC) 的异常. 在thalamic亚区域和皮质区域之间增加的FC与FES患者的认知缺陷和负面症状相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 之前的研究表明,精神分裂症的全大脑乳头功能连接 (FC) 异常.
- 在第一发精神分裂症 (FES) 中,亚区域性thalamic FC和认知缺陷之间的特定关系尚未被探索.
研究的目的:
- 调查第一个发作精神分裂症 (FES) 的亚区域性乳头功能连接 (FC).
- 检查这些FC异常与FES患者的认知缺陷和临床症状之间的相关性.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于在FES患者和健康对照者 (HCs) 之间比较全脑FC与thalamic亚区域.
- 在以前未服用药物的患者中,单独分析了FC变化.
- 研究了FC异常,认知障碍和临床症状之间的相关性.
主要成果:
- 与HCs相比,FES患者在特定的thalamic亚区域和皮质区域 (例如,中叶,cuneus gyrus,中部上部前部,下部/上部部) 之间显示出增加的FC.
- 在某些thalamic亚区域和左下额头三角之间观察到降低FC.
- 社会认知和视觉学习的缺陷与增加的FC相关,涉及右上尾和尾.
- 阴性症状严重程度与thalamic亚区域和左侧中圈之间增加的FC有关.
结论:
- 第一发精神分裂症 (FES) 患者表现出thalamic亚区域和皮质区域之间的功能连接 (FC) 异常.
- 乳头皮层FC增加与FES的认知缺陷和负面症状有关.
- 这些发现强调了状皮层连接在精神分裂症病理生理学的重要性.
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