作为多模块联合交付平台的DNA纳米设备,用于结合癌症免疫治疗
Cunpeng Nie1, Jingxuan Ye1, Jian-Hui Jiang1
1State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Journal of colloid and interface science
|April 14, 2024
概括
这项研究引入了一种用于癌症免疫治疗的新型DNA纳米装置,有效地提供多种免疫刺激剂,以对抗瘤并预防最小毒性转移.
科学领域:
- 生物技术是生物技术.
- 癌症研究 癌症研究
- 免疫学 免疫学 免疫学
背景情况:
- 癌症免疫疗法在提供多种免疫刺激剂以克服免疫抑制瘤微环境 (TME) 方面面临挑战.
- 有效的传递系统对于增强抗瘤免疫反应和重编程TME至关重要.
研究的目的:
- 开发一种DNA纳米器件,以有效地同时提供多种免疫调节剂.
- 通过重编程TME并引起强大的抗瘤反应来增强癌症免疫疗法.
主要方法:
- 组装了一个DNA纳米设备,其中包含多克索鲁比 (Dox),双链DNA (dsDNA),介质蛋白-12 (IL-12) 和小发针编程细胞死亡连接体1 (shPD-L1) 转录模板.
- 利用循环[Arg-Gly-Asp-(d-Phe) -Cys] (cRGD) 用于向的输送和二硫化键的释放,以触发谷氨 (GSH) 的释放.
- 研究了纳米设备对瘤细胞死亡,抗原呈现细胞 (APC) 激活,免疫细胞透和TME调节的影响.
主要成果:
- 多克斯诱导免疫细胞死亡 (ICD) 和增强APC细胞化.
- 在APC中激活干扰素基因 (STING) 信号的dsDNA激活刺激器.
- 该纳米装置促进了CD8+和CD4+T细胞的透,产生炎症的TME并提高了免疫治疗的有效性.
- 显著抑制瘤生长和预防肺转移,没有明显的全身毒性.
结论:
- 开发的DNA纳米装置是癌症组合治疗的有希望的策略.
- 这种方法有效地重编程TME并增强抗瘤免疫力.
- 该纳米设备为有效和向的癌症治疗提供了潜在的解决方案,并降低了全身毒性.
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