低系统性炎症反应指数与腺囊性癌患者的生存率改善有关
Xuanqi Feng1, Zhongyang Sun2, Yang Huang3
1Graduate Student, Medical School of Chinese PLA, Beijing, China.
概括
系统性炎症反应指数 (SIRI) 可以预测头腺囊性癌 (ACCHN) 患者的长期存活率. 较高的SIRI值与较差的结果有关,这表明它作为预后工具的实用性.
科学领域:
- 在瘤学瘤学.
- 炎症标记物 炎症标记物
- 癌症预后 癌症预后
背景情况:
- 预测腺囊性癌 (ACC) 的长期存活是具有挑战性的.
- 基于炎症细胞的指数越来越被认为是瘤学中有价值的预后指标.
研究的目的:
- 调查手术前全身炎症反应指数 (SIRI) 和全身免疫炎症指数 (SII) 之间的关联,以及头 ACC (ACCHN) 患者的10年生存率.
主要方法:
- 对162名ACCHN患者进行了回顾性队列研究.
- 系统性炎症反应指数 (SIRI) 和系统性免疫炎症指数 (SII) 在手术前进行计算.
- 使用尤登指数确定最佳切割值.
- 用Cox比例风险回归和Kaplan-Meier分析来评估预后对整体存活时间 (OS) 的意义.
主要成果:
- 该研究包括162名ACCHN患者,随访时间中位数为6.81年;10年的OS率为7.68%.
- 系统性炎症反应指数 (SIRI) 被确定为OS的独立预后因素 (P < .01;危险比,2.45).
- 较高的SIRI值与ACCHN患者的长期存活率较差显著相关.
结论:
- 手术前系统性炎症反应指数 (SIRI) 是头腺囊性癌患者长期生存的重要和独立预测指标.
- SIRI具有可复制性,方便性,非侵入性和可负担性的优势,将其定位为ACCHN的有希望的预后工具.
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