在人类中,原生依赖葡萄糖的胰岛素型多的安全性
Mads M Helsted1, Nina L Schaltz1, Lærke S Gasbjerg2
1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Peptides
|April 14, 2024
概括
在各种人群中进行的短期人类研究中,合成人类依赖葡萄糖的胰岛素型多 (GIP) 药物似乎是安全的. 大多数研究报告没有任何不良事件,暂时心率增加是观察到的最常见问题.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 葡萄糖依赖型胰岛素型多 (GIP) 是一种涉及葡萄糖调节的隐形激素.
- 人工GIP类型正在研究代谢障碍的治疗潜力.
- 评估GIP的安全性对其临床发展至关重要.
研究的目的:
- 在人体研究中系统地审查与合成人体GIP{1-42) 管理相关的安全性和不良事件.
- 为了评估GIP的耐受性{1-42}在不同的参与者群体和研究持续时间.
主要方法:
- 在PubMed数据库上进行了系统的文献搜索,寻找涉及合成人类GIP的试验.
- 包括的研究涵盖了广泛的参与者表型,包括健康人群和患有各种糖尿病类型和相关疾病的人群.
- 关于报告的安全事件,研究持续时间和GIP药理动力学的数据被提取和分析.
主要成果:
- 包括67项研究,持续时间从30分钟到6天.
- 大多数研究 (78%) 没有报告安全事件.
- 当报告时,最常见的不良事件是心率的适度,短暂的增加,其他胃肠道事件和血压变化也被注意到. 没有发现GIP度和安全事件之间的相关性.
结论:
- 在人体研究中,合成人体GIP的短期 (长达6天) 管理似乎通常被很好地容忍.
- 长期连续使用GIP的安全性仍然未知,需要进一步研究.
- GIP{1-42) 呈现出线性剂量依赖的血度增加和在不同参与者群体中一致的清除率.
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