在NMOSD患者中,白物质网络和灰白物质功能网络的功能连接异常
Xincui Wan1, Yingjie Tang2, Yu Wu3
1Department of Radiology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China.
Brain research bulletin
|April 14, 2024
概括
神经脊髓炎光学谱系障碍 (NMOSD) 患者经常经历认知障碍. 这项研究在NMOSD中发现异常白质 (WM) 功能网络,与认知缺陷相关,并影响大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 认知科学 认知科学
背景情况:
- 认知障碍 (CI) 影响了神经髓炎光学谱障碍 (NMOSD) 患者的很大一部分.
- 白质 (WM) 功能网络在NMOSD认知功能障碍中的作用仍未得到充分研究.
研究的目的:
- 调查NMOSD患者在WM网络中的功能连接 (FC),自发活动和功能共变连接 (FCC) 的异常.
- 评估这些WM网络异常与认知表现之间的相关性.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于24名NMOSD患者和24名健康对照 (HC).
- 分析包括创建WM和灰色物质 (GM) 网络,评估FC,自发活动和FCC.
- 用蒙特利尔认知评估 (MoCA) 评估认知功能.
主要成果:
- 与HC相比,NMOSD患者在多个WM网络中表现出降低的FC和减少的自发活动.
- 在GM网络及其与WM网络的连接中也观察到异常.
- 三分之二的NMOSD患者在MoCA上显示CI,WM网络中的FC和FCC与MoCA得分负相关.
结论:
- WM功能网络显示多层复杂性,并在NMOSD中显著改变.
- 在WM和GM功能网络中的异常可能是NMOSD认知障碍的贡献者.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.1K
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
7.9K
相关概念视频
Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Disorders of the Nervous Tissue
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Network Function of a Circuit
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
MOSFET: Enhancement Mode
Enhancement-mode MOSFETs are pivotal components in electronics, distinguished by their capacity to act as highly efficient switches. They are part of the larger family of metal-oxide Semiconductor Field-Effect Transistors (MOSFETs). They are available in two types: p-channel and n-channel, each tailored to specific polarity operations.
In their basic form, enhancement-mode MOSFETs are typically non-conductive when the gate-source voltage (Vgs) is zero. This default 'off' state means no current...
In their basic form, enhancement-mode MOSFETs are typically non-conductive when the gate-source voltage (Vgs) is zero. This default 'off' state means no current...
MOSFET: Depletion Mode
Depletion-mode MOSFETs represent a unique subset of MOSFET technology, functioning fundamentally differently from their enhancement-mode counterparts. Unlike enhancement MOSFETs, which require a positive gate-source voltage (Vgs) to turn on, depletion-mode MOSFETs are inherently conductive and "normally on" devices.
The primary characteristic of depletion-mode MOSFETs is their ability to conduct current between the drain and source terminals without gate bias. This inherent conductivity arises...
The primary characteristic of depletion-mode MOSFETs is their ability to conduct current between the drain and source terminals without gate bias. This inherent conductivity arises...
