前肢皮层-核 accumbens 核心投射积极调节和与相关的厌恶
Jun-Hui Long1, Pu-Jun Wang1, Li Xuan2
1Southwest Hospital Jiangbei Area (The 958th hospital of Chinese People's Liberation Army), Chongqing, China.
Behavioural brain research
|April 14, 2024
概括
前临床皮层 (Prl) - 核 accumbens 核心 (NAcC) 途径调节和相关的负面情绪. 抑制这种途径可以减少伤行为和厌恶,这表明它在感知中的作用.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
背景情况:
- 是与皮肤,肝脏和脏疾病相关的常见症状,通常会引起痛苦和伤.
- 前极皮层 (Prl) 和核核 (NAcC) 参与调节.
- 在和负面情绪中Prl-NAcC投影的作用仍然不清楚.
研究的目的:
- 调查Prl-NAcC投影在和相关的负面情绪中的参与.
- 探索和其情感成分的调节机制.
主要方法:
- 已建立的急性的老鼠模型使用5-HT,化合物48/80或.
- 利用免疫光检测神经元活动 (c-Fos表达) 在Prl.
- 采用化学遗传学来抑制Prl谷氨基质神经元和Prl-NAcC投射.
主要成果:
- 急性增加了Prl中的c-Fos表达.
- 化学遗传抑制Prl神经元或Prl-NAcC投射减少了基因组和非基因组 خار行为.
- 抑制还纠正了与非胰腺激素相关的有条件地厌恶 (CPA) 行为.
结论:
- Prl-NAcC投影在积极调节-抓行为方面发挥着重要作用.
- 这一途径调解与有关的负面情绪.
- 准Prl-NAcC通路可能为相关疾病提供治疗潜力.
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