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使用基于carboxyethyl-succinoglycan的降解反应性水凝进行药物递送,具有高度改善的风湿学,抗菌和抗氧化特性

Yohan Kim¹, Kyungho Kim¹, Jae-Pil Jeong¹

¹Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea.

Carbohydrate polymers

|April 14, 2024

概括

高粘度的碳氧乙基-糖甘 (CE-SG) 由糖甘 (SG) 合成,显示出增强的粘度,热稳定性以及强大的抗菌和抗氧化特性,用于生物材料应用.

科学领域:

生物技术是生物技术.
聚合物科学聚合物科学
材料科学材料科学材料科学

背景情况:

基于外聚糖的聚合物在工业生物技术中越来越多地被使用.
糖糖 (SG) 是一种有前途的外聚糖体,用于材料开发.
修改SG可以提高其功能性质.

研究的目的:

从SG中合成和描述高粘度的碳氧乙基糖 (CE-SG).
调查CE-SG的结构,质和生理性质.
探索CE-SG作为一种功能生物材料的潜力.

主要方法:

从Sinorhizobium meliloti Rm 1021中分离出来的糖 (SG) 经过化学修饰,使用3- propionic 酸产生碳氧乙烯-糖 (CE-SG).
评估了CE-SG的结构性,性 (粘度,热稳定性) 和生理性 (抗菌,抗氧化剂) 特性.
用Fe3+离子形成了CE-SG水凝,并评估了它们的特性,包括减少反应药物释放.

主要成果:

随着碳氧乙基化程度的提高,CE-SG粘度显著增加,特别是在SG与3-烯酸的摩尔比率为1:100时增加了21.18倍.
与未经修改的SG相比,CE-SG表现出增强的热稳定性.
CE-SG对大肠杆菌和黄金葡萄球菌 (超过90%) 具有强烈的抗菌活性,并具有有效的抗氧化能力.
与Fe3+离子协调的CE-SG水凝显示出改善的质性质,并表现出减少响应的药物释放.

结论:

碳氧乙基化是一种有效的方法,可以提高糖的粘度和功能性质.
作为一种功能性生物材料,CE-SG在食品,化品和制药行业的应用中具有显著的潜力.
像CE-SG这样的SG衍生品的开发为先进的材料需求提供了多功能解决方案.

关键词:

抗菌和抗氧化作用抗菌和抗氧化作用碳氧乙基化碳氧乙基化.水凝是一种水凝.降低响应药物递送的药物递送.类风病学类风病学类风病学葡萄糖糖可以是糖.

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