公众对NHS中药物遗传测试的偏好:在服务设计中嵌入离散选择实验,以更好地满足用户需求
John H McDermott1,2, Videha Sharma3, William G Newman1,2
1Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
British journal of clinical pharmacology
|April 14, 2024
概括
英国成年人更喜欢非侵入性药物遗传测试,而不是个性化医疗. 公众对数据共享和访问的偏好影响了服务采用,突出了未来药物遗传服务发展的关键领域.
科学领域:
- 药物遗传学和个性化医学
- 医疗保健服务研究 医疗服务研究
- 公共卫生基因组学
背景情况:
- 药物遗传学通过基因检测使药物使用更安全,更有效.
- 将药物遗传服务纳入初级保健是国家卫生服务 (NHS) 的一个关键考虑因素.
研究的目的:
- 确定英国公众对初级保健中药物遗传检测服务的偏好.
- 根据不同的服务设计量化潜在的采用.
主要方法:
- 在1993年英国对1993年英国个人进行的在线调查,提出了低情绪或疼痛的假设情景.
- 条件逻辑模型和潜在类分析以确定偏好和异质性.
- 基于不同设计特征的服务采用率估计.
主要成果:
- 临床情景之间没有显著的偏好差异 (低情绪与疼痛).
- 强烈偏好非侵入性测试,跨医疗机构的数据共享和区域数据倡议.
- 个人希望个人访问他们的遗传数据.
结论:
- 公共偏好强烈支持药物遗传服务的非侵入性方法和数据共享.
- 服务设计显著影响预测的采用率,从51%到99%以上.
- 研究结果为英国未来药物遗传服务的优先级和发展提供了关键的见解.
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