纵向光学连贯性断层扫描指数在异常性内高血压中
Rachel Shemesh1,2,3, Omry Frige2,3, Sharon Garmider3
1Neuro-Ophthalmology Unit, The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
Scientific reports
|April 14, 2024
概括
异形性内高血压 (IIH) 导致视神经随着时间的推移而变薄. 该研究发现,最初的疾病严重程度预测了视网膜神经纤维层 (RNFL) 稀薄的时间和程度.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
背景情况:
- 异形性内高血压 (IIH) 可以导致不可逆转的视神经损伤,包括纤维损失和缩.
- 光学连贯断层扫描 (OCT) 索引和IIH解剖结果的预测指标的时间动态尚不清楚.
研究的目的:
- 为了确定视网膜神经纤维层 (RNFL) 厚度点在IIH患者的时间过程.
- 确定预测纳迪尔RNFL厚度和IIH整体解剖结果的因素.
主要方法:
- 对2009年12月至2020年1月期间接受治疗的99名IIH患者的医疗记录的回顾性审查.
- 分析光学连贯性断层扫描 (OCT) 数据,包括RNFL和质细胞复合体 (GCC) 厚度,在呈现和随着时间的推移.
- 相关性分析以确定基线参数,时间到极点和极点值与视觉场结果之间的关系.
主要成果:
- 达到最低RNFL厚度的平均时间为7.9个月.
- 在顶点,RNFL的平均厚度为92.6μm (47%的稀释),GCC的平均厚度为77.9μm (70%的稀释).
- 更高的弗里森盘胀阶段和更厚的基线RNFL与更长的时间相相关. 纳迪尔RNFL和GCC厚度与基线视野平均偏差相关,表明IIH在呈现时的严重程度会影响RNFL和GCC稀薄.
结论:
- 在IIH发作中的最终解剖结果以RNFL和GCC稀释为特征.
- 达到RNFL最低点的时间和最低点值与IIH在呈现时的严重程度有显著的相关性.
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