系统治疗对HER2-阳性和三阴性乳腺癌的进展:外科医生需要知道的
Stephanie Downs-Canner1, Anna Weiss2
1Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Clinical breast cancer
|April 15, 2024
概括
新辅助全身疗法 (NST) 通过使乳腺保存和根据反应量身定制疗法来推进乳腺癌治疗. 对于HER2+和三阴性乳腺癌 (TNBC),NST降级策略正在发展.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 临床试验设计 临床试验设计
背景情况:
- 新辅助全身疗法 (NST) 越来越多地用于无法切除的病例,以改善乳腺保护和治疗计划.
- 临床试验已经使 HER2-阳性和三阴性乳腺癌 (TNBC) 的个性化NST疗法成为可能.
研究的目的:
- 审查新辅助全身疗法 (NST) 在乳腺癌管理中的演变作用.
- 讨论降级策略及其对HER2+和TNBC治疗决策的影响.
- 突出外科和多学科团队参与NST临床试验的重要性.
主要方法:
- 对临床试验结果和新辅助全身疗法的治疗指南的审查.
- 在HER2+和TNBC新辅助环境中分析降级策略.
- 对接受NST的患者进行手术可行性和安全性的评估.
主要成果:
- NST有助于乳房的保存和股下降阶段,告知辅助治疗.
- 缓解化疗和免疫治疗方案的升级对HER2+和TNBC有效.
- 在符合条件的患者中,乳房保护和哨兵淋巴结活检在NST后是安全的.
结论:
- 新辅助全身疗法是大多数HER2+和TNBC患者的基石,目前正在努力改进治疗选择.
- 降级试验对于最大限度地降低毒性,同时保持有效性至关重要.
- 外科医生和多学科团队的合作对于成功实施NST和采用临床试验至关重要.
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