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探索结性脊柱炎和炎症性肠病之间的联系:一个回顾性队列研究
Kassem Sharif1, Adi Lahat1, Yonatan Shneor Patt2
1Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Department of Gastroenterology, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
结性脊柱炎 (AS) 患者患上炎症性肠病 (IBD) 的风险明显更高. 这强调了需要提高AS患者对IBD症状的认识和多学科方法.
科学领域:
- 风湿病学和胃肠道学
- 慢性疾病流行病学 慢性疾病流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 结节性脊柱炎 (AS) 和炎症性肠病 (IBD) 具有共同的致病机制和遗传倾向.
- 关于AS和IBD之间综合性关系的证据仍在争论中,一些研究支持联系,而另一些则不支持.
研究的目的:
- 调查AS诊断与随后IBD发病率之间的关联.
- 在AS-IBD关系中识别潜在的风险因素和影响修饰因素.
主要方法:
- 使用克莱利特卫生服务 (2002-2018) 慢性疾病注册表进行回顾性队列研究.
- 对AS患者 (n=5825) 与年龄和性别匹配的对照人群 (n=28,356) 进行了比较,不包括以前有IBD的患者.
- 考克斯的比例危险模型被用于评估IBD风险,并对并发症和人口统计进行了调整.
主要成果:
- 与对照组相比,AS患者的IBD发病率明显高.
- 多变量分析显示,在AS患者中,克罗恩病的危险比为6.09,性结肠炎的危险比为2.31.
结论:
- 结性脊柱炎患者面临着明显增加的IBD发展风险.
- 建议加强对AS患者IBD症状的临床警,并采取多学科护理方法.
- 对共享的致病途径的进一步研究对于个性化治疗策略至关重要.
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