在非免疫功能低下的重症患者中感染细胞巨乳病毒:管理视角
Madhura Bhide1, Omender Singh1, Prashant Nasa2
1Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India.
World journal of virology
|April 15, 2024
概括
危急病患者由于免疫力减弱而面临细胞巨乳病毒 (CMV) 感染的风险增加. 了解CMV症状,诊断和治疗对于在重症监护病房 (ICU) 中改善患者的治疗结果至关重要.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 危急病患者容易感染二次感染,包括细胞巨乳病毒 (CMV),由于严重疾病,长时间的ICU住院和免疫抑制疗法等因素.
- 高达33%的ICU患者发生CMV血清转化,但其临床意义和对结果的影响仍在争论中.
- 目前对CMV管理的指导方针主要针对免疫功能受损的个体 (例如,艾滋病毒/艾滋病),对免疫能力较强的重症患者的理解存在差距.
研究的目的:
- 突出诊断和管理危急病患者中细胞巨乳病毒 (CMV) 感染的挑战.
- 强调需要更好地了解CMV症状学,诊断方法和重症监护室 (ICU) 设置中的治疗策略.
- 提供可以帮助重症监护医生准确诊断和在脆弱患者群体中及时启动CMV治疗干预措施的见解.
主要方法:
- 复习现有的关于重症患者中细胞巨乳病毒 (CMV) 感染的文献.
- 分析导致ICU免疫衰竭和机会性感染的因素.
- 讨论诊断挑战,包括非特异性症状和多器官参与.
主要成果:
- 细胞巨乳病毒 (CMV) 感染是重症患者的重大机会性感染,在ICU中血清转化率高达33%.
- 在这种人群中,CMV的诊断因非特异性临床表现和潜在的多器官功能障碍而复杂化.
- 对于免疫能力严峻的重症患者中CMV的最佳治疗和干预的必要性仍然不清楚.
结论:
- 细胞巨乳病毒 (CMV) 对重症患者构成风险,需要更清楚地了解其临床影响.
- 改进的诊断工具和定义的治疗方案对于在重症监护机构管理CMV至关重要.
- 需要进行进一步的研究,以建立基于证据的指导方针,用于CMV诊断和治疗免疫能力强的重症患者.
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