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Biofunctionalization of Magnetic Nanomaterials
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非漂白的生物杀伤性N-哈拉胺功能化聚胺,关尼丁和水胺基涂料
Lev Bromberg1, Beatriz Magariños2, Angel Concheiro3
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Industrial & engineering chemistry research
|April 15, 2024
概括
新的生物杀伤剂涂层是使用含有瓜尼丁和水丁组的聚合物开发的. 这些耐用,可重复使用的N-halamine表面通过接触杀死有效地禁用冠状病毒,为未来的流行病提供了更好的保护.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 表面化学 表面化学
背景情况:
- 抗微生物纤维材料为重复使用和减少感染提供实时微生物失活.
- 抗病毒聚合物涂层可以增强表面功能,防止当前和未来的病毒威胁.
研究的目的:
- 开发一种简单的方法,使用具有核性比古安化,瓜尼丁和antoin 基团的聚合物来创建生物杀菌表面.
- 在各种织物和玻璃纤维上创建稳定,不水,可重复使用的抗病毒涂层.
主要方法:
- 生物杀菌聚合物 (PVG,PAH,PVAm,PHMB) 通过西洛或异酸盐前体对固体支物的共价附着.
- 聚合物涂层织物的化,使用二酸盐或低酸形成N-胺表面 (>N-Cl或>N-Br).
- 通过多个洗衣周期测试涂层的稳定性,并评估对人类呼吸道冠状病毒的抗病毒疗效.
主要成果:
- 在棉花,尼龙-棉花和玻璃纤维面料上开发了稳定,不漂白和可重复使用的聚合物涂层.
- 在涂层表面上达到高活性N-胺组 (>N-Cl或>N-Br) 的含量.
- 通过接触杀死证明了人类呼吸道冠状病毒的完全禁用,表面在充电后可重复使用.
结论:
- 开发的接种和化方法提供了一个可行的途径,以创建持久的,可重复使用的生物杀菌N-胺表面.
- 这些抗病毒涂层显示出需要微生物无活化和防治病毒流行病的应用的巨大潜力.
- 这些材料在多次使用和充电周期后仍然保持其水友性质和生物杀伤性质.
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