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一种基于对比增强超声波的诺莫图,用于评估移植脏中质硬化率
Nan Xu1, Dandan Wang1, Yi Hong2
1Department of Ultrasound, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Quantitative imaging in medicine and surgery
|April 15, 2024
概括
增强对比的超声波 (CEUS) 可以预测移植脏中的淋巴细胞硬化症. 这种新的成像生物标志物显示出早期检测和改善患者结果的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 放射学 放射学是一门学科.
- 移植医学 移植医学 移植医学
背景情况:
- 移植脏中高血球硬化率表明预后不佳.
- 早期预测质样硬化症对于治疗移植患者至关重要.
- 与对比度增强的超声波 (CEUS) 被探索为一种新的成像生物标志物.
研究的目的:
- 为了评估CEUS用于早期预测质结核病率在脏全移植.
- 评估CEUS参数在识别高淋巴结核硬化率方面的有效性.
- 开发一个预测模型,用于细胞硬化在移植接受者.
主要方法:
- 对143名确诊病理的移植接受者的回顾性分析.
- 进行了传统的超声波 (CUS) 和CEUS检查.
- 多变量物流分析和名ogram构造被用来识别预测因素.
主要成果:
- 在高于50%和低于50%的血球样硬化群体之间观察到CEUS参数 (PI,ATTP,TTP) 的显著差异.
- 峰值强度,皮层间动脉PSV,皮质回声性和移植后的时间是独立的预测因素.
- 开发的名图表显示出高的预测准确性 (在训练中AUC为0.914,在验证中为0.909).
结论:
- 结合CUS,CEUS和临床数据的诺莫图有效预测移植脏中的淋巴结核硬化率.
- CEUS显示出作为早期检测的非侵入性成像生物标志物的潜力.
- 这种预测模型可以提高移植管理中的临床决策.
相关概念视频
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The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
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The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
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