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与卵子捐赠者相比,青少年的卵子微环境发生了变化
Dilan Gokyer1, Sophia Akinboro1,2, Luhan T Zhou1
1Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611.
bioRxiv : the preprint server for biology
|April 15, 2024
概括
与成年捐赠者相比,青少年的生育性保护显示了积细胞 (CC) 基因表达和卵泡液 (FF) 细胞因子配置的改变. 这些分子差异可能会影响年轻患者的卵细胞质量.
科学领域:
- 生殖生物学 生殖生物学
- 分子遗传学 分子遗传学
- 在瘤学瘤学.
背景情况:
- 接受生育保护的青少年表现出独特的生殖特征,包括与卵细胞无倍积分相关的潜在次繁殖性.
- 哺乳动物的繁殖年轻期与卵细胞质量下降有关.
研究的目的:
- 为了研究青少年和成人卵细胞捐赠者之间的卵细胞微环境中的分子差异,以保护生育能力.
- 为了比较累积细胞 (CCs) 的转录组形状和毛囊液 (FF) 中的细胞因子水平.
主要方法:
- 前性队列研究,比较青少年 (10-19岁) 和成年卵细胞捐赠者 (22-30岁).
- 批量RNA测序CCs和FF的细胞因子阵列分析.
- 分析了CC中581个差异表达基因 (DEG) 和FF中9个显著改变的细胞因子.
主要成果:
- 与成年人相比,青少年的CCs显示了细胞周期/分裂基因的下调和细胞/囊泡组织基因的上调.
- 青少年FF显著增加了9种细胞因子的水平,其中7种具有已知的促炎作用.
- 在患有或没有癌症的青少年之间,没有观察到CC转录组或FF细胞因子概况的显著差异.
结论:
- 青少年的卵细胞微环境在分子上不同于生殖性成人卵细胞捐赠者的卵细胞微环境.
- 这些CC基因表达和FF细胞因子的变化可能为接受生育保护的年轻患者的性质和生殖潜力提供见解.
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