条件删除CEACAM1导致肝星细胞激活
bioRxiv : the preprint server for biology
|April 15, 2024
概括
肝星细胞 (HSC) 中CEACAM1的损失会激活它们,导致肝纤维化. 这通过EGFR通路的激活发生,独立于胰岛素耐药性或肥胖症.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 细胞生物学 细胞生物学
- 分子医学是分子医学.
背景情况:
- 肝脏CEACAM1 (癌胚抗原细胞粘附分子1) 表达在患有代谢功能障碍相关的脂肪肝炎 (MASH) 的患者中,晚期肝纤维化下降.
- 肝细胞中CEACAM1缺乏会损害胰岛素清除,导致胰岛素耐药性和肥胖症,并通过激活的肝星细胞 (HSC) 促进肝炎和纤维化.
结论:
- 在HSC中CEACAM1的丧失直接诱导它们的肌纤维细胞转化,导致肝纤维化.
- 这种HSC激活发生的独立于肝脏胰岛素耐药性和胆固醇症.
- 这一过程是由EGFR通路的自克林激活驱动的,在HSC中放大了炎症和扩散.
相关概念视频
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K